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Liver disease and cancer risks linked to lifestyle and metabolic health

Liver disease and liver cancer cases are rising globally, driven by factors such as poor diet, lack of exercise, and metabolic conditions. Cirrhosis, characterized by the replacement of healthy liver tissue with scar tissue, often develops slowly over many years. Because early damage may present few obvious symptoms, the disease is frequently discovered only after complications arise.

Key warning signs include extreme fatigue, jaundice (yellowing of the skin or eyes), and swelling. In women, liver disease may also manifest as hormonal imbalances or irregular menstrual periods.

Medical experts highlight several lifestyle factors that contribute to liver damage. Excessive alcohol consumption, particularly binge drinking, can lead to steatotic liver disease, where fat accumulates in the liver, causing inflammation and scarring. This risk is compounded for individuals with metabolic issues like Type 2 diabetes or high blood pressure. Additionally, high sugar consumption is linked to fat buildup in the liver and insulin resistance. Experts suggest that lifestyle and dietary changes may help prevent or even reverse certain stages of liver disease.

Entities

Dr Mary Rinella · Dr Zobair Younossi · Georgetown University School of Medicine · University of Chicago