Medical researchers uncover new mechanisms in T-cell immunity and inflammation

Researchers have made significant discoveries regarding immune responses and inflammation. At McGill University, a study led by Professor Judith Mandl suggests that T-cells possess a sensory capability that allows them to detect the stiffness of surrounding tissue. This physical feedback influences whether they develop into tissue-resident memory T-cells, which are crucial for long-term immunity. This finding, conducted in collaboration with American and Dutch researchers, could impact future treatments for cancer, allergies, and autoimmune diseases.

Separately, scientists at Lund University have identified a mechanism explaining how the breakdown of red blood cells drives inflammation. When red blood cells rupture, the release of free heme triggers a chain reaction involving factor XII and the kallikrein-kinin system. This process leads to the release of bradykinin, which increases blood vessel permeability and can cause swelling and blood pressure drops. The study, which included analysis of children with hemolytic uremic syndrome, suggests that this inflammatory reaction could potentially be slowed using the drug C1-inhibitor.