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[HEALTH] · United States, United Kingdom, Singapore, Congo - Kinshasa · 8 sources

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Merck and Wellcome move forward with Bundibugyo Ebola vaccine production

Merck and the global charity Wellcome are advancing a candidate vaccine against the Bundibugyo strain of Ebola through their Singapore‑based joint venture, Hilleman Laboratories. The effort, supported by up to $8.5 million from the Coalition for Epidemic Preparedness Innovations (CEPI), aims to manufacture doses for early‑stage clinical trials that could begin by the end of the year.

The vaccine candidate, developed by the International AIDS Vaccine Initiative and highlighted by the World Health Organization as the most promising, uses the recombinant vesicular stomatitis virus (rVSV) platform also employed in Merck’s licensed Ervebo vaccine for the Zaire Ebola strain. CEPI is also funding other candidates – up to $8.6 million for an Oxford‑based vaccine and $50 million for a Moderna version.

The push comes as the Bundibugyo Ebola outbreak in eastern Democratic Republic of Congo has infected 3,360 people and killed 1,487 as of July 29, with no approved treatments currently available.

Entities

Coalition for Epidemic Preparedness Innovations (CEPI) · Hilleman Laboratories · International AIDS Vaccine Initiative · Merck & Co. · Wellcome

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