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[TECHNOLOGY] · United States · 7 sources

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Mount Sinai launches bioengineered human tissue models to the ISS

Researchers from Mount Sinai, in collaboration with NASA and Space Tango, have launched bioengineered human brain and cardiovascular tissue models to the International Space Station (ISS). The biological payloads, transported via the SpaceX CRS-35 mission, include miniature organ-like systems known as organoids and microfluidic ‘organ-on-a-chip’ systems.

The mission aims to study how microgravity and increased radiation exposure affect human health, specifically focusing on neurological signaling, vascular dynamics, and cellular stress. The miBrain platform, derived from patient stem cells, will be used to evaluate how these spaceflight conditions influence neurodegeneration and genetic risk factors, such as the APOE4 allele associated with Alzheimer’s disease.

Additionally, the µCVchip platform will test up to 16 miniature hearts to monitor their response to electrical signals and near-zero gravity. Because spaceflight can simulate accelerated aging—where six months in orbit may be equivalent to 10 to 20 years on Earth—these models provide a unique opportunity to study disease progression and develop countermeasures for both future astronauts and people on Earth.

Entities

Cape Canaveral Space Force Station · International Space Station · Mount Sinai · Mount Sinai Health System · NASA · Space Tango · SpaceX

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