New blood biomarkers predict subclinical atherosclerosis

Two novel blood biomarkers have been identified that can predict the presence of subclinical atherosclerosis and subsequent cardiovascular events. Atherosclerosis involves the progressive accumulation of lipids, inflammatory cells, and fibrous tissue in arterial walls, often progressing silently for decades before causing acute events like heart attacks or strokes.

While traditional risk factors such as hypertension, diabetes, and obesity help estimate population-level risks, they are limited in precisely identifying individuals developing early-stage atherosclerosis. Although non-invasive imaging like ultrasound can improve risk stratification, these technologies are not universally available. Consequently, there is significant medical interest in developing rapid, non-invasive methods, such as plasma biomarker measurement, to improve the detection of atherosclerotic plaques.