New Studies Reveal Creatine and B‑cell Mechanisms Enhance Cancer Immunotherapy

A UCLA study identified creatine, a common gym supplement, as a critical fuel for tumor‑infiltrating dendritic cells. Supplementing mice with creatine raised intracellular ATP in these cells, increased their activation, and significantly slowed tumor growth in melanoma models.

Separate research demonstrated that anti‑CTLA‑4 checkpoint therapy for brain tumors relies on a robust B‑cell and antibody response originating in the deep cervical lymph nodes of the neck. The generated IgG antibodies travel to the brain, bind glioma cells, and facilitate macrophage‑mediated destruction, making B cells essential for the therapy’s success.