NEXAF trial shows exercise reduces atrial fibrillation burden

A one-year exercise program has been shown to reduce the burden of atrial fibrillation (AF) and improve quality of life in symptomatic patients, according to results from the NEXAF trial presented at the ESC Congress 2026.

The study, led by Dr. Bjarne Nes of the Norwegian University of Science and Technology, involved patients with non-permanent AF and low physical activity levels. Participants were randomized to either a structured exercise intervention or usual care. The intervention included eight supervised high-intensity sessions during the initial four to six weeks, followed by long-term home-based exercise supported by remote monitoring via smartwatches, apps, and web-based platforms.

Researchers noted a significant implementation gap in current medical practice; despite guidelines, only about 1 in 10 eligible patients are currently referred for exercise-based rehabilitation. The NEXAF trial aimed to address previous limitations in research by providing continuous monitoring of AF burden over a sustained one-year period.