NFL releases 2026 Week 1 schedule and betting odds

The NFL has released the Week 1 schedule for the 2026 season, featuring a full 16-game slate of action. The opening campaign is set to begin with a matchup between the New England Patriots and the Seattle Seahawks on Wednesday, September 9th.

Other notable opening week matchups include the San Francisco 49ers against the Los Angeles Rams and the Buffalo Bills against the Houston Texans. Betting odds and point spreads have been established for the various games scheduled through Monday, September 14th.