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[HEALTH] · United States · 3 sources

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Oxaloacetate supplement may reduce brain fog in breast cancer survivors

oxaloacetate breast cancer survivors cognitive impairment brain fog UCLA Health

A small clinical study conducted by researchers at the UCLA Health Jonsson Comprehensive Cancer Center suggests that oxaloacetate, a molecule naturally present in the body, may help alleviate cognitive impairment in breast cancer survivors.

The study, published in JCO Oncology Advances, focused on women with early-stage breast cancer who were one to five years post-diagnosis. Participants reported symptoms often referred to as “chemo brain” or “brain fog,” including difficulties with memory, concentration, fatigue, and planning.

During the eight-week trial, participants took 500 milligrams of oxaloacetate twice daily. Of the 18 women who joined, 16 completed the study. All 16 reported improvements in cognitive symptoms, with testing indicating gains in processing speed and executive function. Participants also reported reduced fatigue and improved physical functioning.

Researchers noted that while the results are promising, the study was limited by a small sample size and the absence of a placebo group, meaning a causal link cannot yet be established. The study aims to address the complex causes of cognitive decline, which may include chemotherapy, hormone treatments, and inflammation.

Entities

David Geffen School of Medicine at UCLA · Dr. Patricia Ganz · JCO Oncology Advances · UCLA Health Jonsson Comprehensive Cancer Center · oxaloacetate

Claims

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Sources

This supplement may ease brain fog after breast cancer [knowridge.com]
Oxaloacétate : un supplément pourrait réduire le brouillard mental [www.nouvelles-du-monde.com]
Oxaloacetate supplement may help reduce chemo brain in breast cancer survivors [www.news-medical.net]