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Placental cell nasal spray shows promise in Alzheimer's research
Researchers in Italy are investigating a potential new treatment for Alzheimer's disease using a nasal spray composed of extracellular vesicles. These tiny particles are derived from mesenchymal stromal cells found in the human amnion membrane (placenta).
While Alzheimer's is commonly linked to beta-amyloid and tau protein deposits, this research focuses on the role of the brain's immune system. Specifically, the study explores how chronic inflammation can damage neurons and their connections. The study, published in the journal ‘Translational Neurodegeneration’, utilized genetically modified mice to test the efficacy of the treatment.
Results indicated that the vesicles administered nasally successfully reached the hippocampus, a brain region critical for memory that is heavily impacted by Alzheimer's. The experimental mice received the spray twice weekly over a six-month period.
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- [● 4 SOURCES] The study aimed to influence brain inflammation caused by immune system activation. www.ikz-online.de · www.tlz.de · www.wr.de
- [● 4 SOURCES] The study results were published in the journal ‘Translational Neurodegeneration’. www.ikz-online.de · www.tlz.de · www.wr.de
- [● 4 SOURCES] Italian researchers are studying the use of placental-derived particles to treat Alzheimer's disease. www.ikz-online.de · www.tlz.de · www.wr.de
- [● 4 SOURCES] The vesicles reached the hippocampus after nasal administration in mice. www.ikz-online.de · www.tlz.de · www.wr.de
- [● 4 SOURCES] The treatment uses extracellular vesicles from mesenchymal stromal cells of the human amnion membrane. www.ikz-online.de · www.tlz.de · www.wr.de
- [● 4 SOURCES] The experimental treatment is administered via a nasal spray. www.ikz-online.de · www.tlz.de · www.wr.de