Protein intake and GLP-1 medications impact appetite and libido

Recent scientific research highlights both the nutritional strategies for weight management and the potential side effects of popular GLP-1 receptor agonist medications, such as Ozempic.

Studies indicate that increasing protein intake can naturally regulate appetite by stimulating the release of satiety hormones GLP-1 and PYY. An experiment at the University of Washington demonstrated that increasing protein from 15% to 30% of total calories led participants to spontaneously consume approximately 440 fewer calories per day, resulting in an average weight loss of 5 kilograms over 12 weeks. High protein diets may also help preserve muscle mass and more effectively reduce visceral fat.

Conversely, research published in journals such as ‘Obesity Pillars’ and ‘Molecular Metabolism’ suggests that GLP-1 medications may cause unintended side effects, including reduced libido. Because the brain regions responsible for appetite regulation also influence reward-seeking behaviors, these drugs may suppress the pleasure response. Additionally, changes in serotonin receptors and physical factors related to body composition may impact sexual function and experience.