Psoriasis linked to erectile dysfunction and sexual difficulties

Research indicates a significant link between psoriasis and erectile dysfunction. Studies suggest that the systemic inflammation associated with psoriasis can damage the endothelium, the inner lining of blood vessels, which is essential for healthy blood flow. Additionally, men with psoriasis face higher risks of comorbid conditions such as type 2 diabetes, high blood pressure, and obesity, all of which contribute to sexual dysfunction.

Genital psoriasis specifically can impact intimacy due to physical discomfort, such as itching and soreness. New clinical analyses presented at the 2026 Fall Clinical Dermatology Conference suggest that ZORYVE (roflumilast), a steroid-free cream and foam, may help mitigate these issues. In phase 3 trials, including the DERMIS and ARRECTOR studies, patients using ZORYVE reported a reduction in sexual difficulties and relationship problems compared to those using a placebo. Notably, among patients with genital involvement, a high percentage reported meaningful relief from itching.