Research explores new therapies for diabetic kidney disease

Researchers are investigating new therapeutic approaches to combat diabetic kidney disease, a condition linked to accelerated kidney aging and rising global health burdens.

A study published in the ‘Chinese Journal of Natural Medicines’ suggests that hederagenin, a plant compound found in ivy and black cumin, may protect kidney health by activating anti-aging genes. This research focuses on addressing cellular senescence—the accumulation of damaged cells in kidney tissue—which is a central factor in diabetic kidney damage. Current treatments like SGLT2 inhibitors can slow progression but cannot fully stop damage or restore function, and they carry risks of side effects for certain groups.

In a separate review published in the ‘Journal of Biomedical Science’, scientists are exploring protein tyrosine phosphatases (PTP) as potential therapeutic targets. Research into PTP1B and SHP2 inhibitors, such as SHP099, has shown renoprotective effects in mouse models. These findings aim to address the increasing economic and medical strain caused by chronic kidney disease, which has seen a significant rise in prevalence globally since 1990.