Research explores yeast pathways for CO2 and methanol conversion

A PhD dissertation submitted to the University of Natural Resources and Life Sciences, Vienna, details research into the design of metabolic pathways for the mixotrophic production of biochemicals. The study focuses on using yeasts, specifically Komagataella phaffii, to convert carbon dioxide (CO2) and methanol into valuable compounds.

By designing alternative assimilation pathways for both CO2 and methanol, the research aims to create more sustainable biochemical production methods that could potentially mitigate climate change. The project utilizes bacterial serine or serine-threonine cycles as blueprints to implement these complex metabolic pathways, requiring significant redirection of central metabolic fluxes to maintain yeast growth.