Researchers develop living patches to treat atopic dermatitis

Researchers are developing a “living patch” to treat atopic dermatitis (eczema) by utilizing engineered living materials (ELM). The project, known as NextSkins, is funded by the European Union and is scheduled to continue until 2027.

Led by Professor Tom Ellis of Imperial College London, the research team is investigating how modified microorganisms, such as bacteria and yeast, can be used for medical treatments. One promising prototype is a thin, skin-like patch. The patch contains modified proteins in its bottom layer that detect specific enzymes released by harmful bacteria during eczema flare-ups. This signal triggers living yeast cells deeper within the patch to produce and release therapeutic molecules exactly where they are needed.

Unlike current topical creams that affect all skin cells and microbes indiscriminately, these patches aim for targeted relief. The technology could eventually be adapted into larger formats, such as sleeves, bandages, or even integrated into clothing to cover broader areas of the skin.