Researchers find ovaries remain biologically active after menopause

New scientific research is challenging the long-held belief that ovaries become dormant after menopause. Studies conducted by researchers at the Oklahoma Medical Research Foundation, Northwestern University, and the Buck Institute for Research on Aging suggest that the organ remains biologically active through significant molecular remodeling.

Using high-resolution proteomics to analyze tissue from postmenopausal women, researchers found that the ovaries continue to reorganize their structure, metabolism, and immune activity for decades. While the reproductive function of releasing eggs ends, the organ undergoes a shift from cellular maintenance to active remodeling. For example, tissue from women in their 50s showed higher levels of proteins linked to gene regulation and tissue structure, while tissue from women aged 70 and older showed stronger signatures of lipid metabolism and innate immunity.

Dr. Michael Stout noted that the ovaries may release pro-inflammatory mediators into the circulation, which could be linked to chronic conditions such as cardiovascular disease. This finding suggests that as women live longer post-menopause, the active nature of the organ may contribute to increased inflammation over time.