Researchers Identify Immune Cells Driving Mosquito Bite Itch

A July 2026 study found that mast cells (hízósejtek) are the key immune cells activated by mosquito saliva. They release histamine, which produces the familiar itching sensation. When a person scratches, nerve endings release Substance P, which re‑activates mast cells and triggers another burst of histamine and other inflammatory mediators, creating a self‑perpetuating cycle of itching and swelling.

Separate research notes that sensitive skin is common, affecting 60‑70 % of women and 50‑60 % of men. The condition stems from a compromised skin barrier that reacts strongly to temperature extremes, hot water, fragrances, harsh soaps, stress and certain dermatologic diseases. Experts advise using fragrance‑free, gentle products, avoiding hot water, and applying barrier‑supporting moisturizers that contain ingredients such as panthenol or bisabolol. Persistent or worsening symptoms should be evaluated by a dermatologist.