Scientific research identifies biological memory in fat tissue affecting weight loss

Scientific research published in Cell Reports suggests that adipose tissue may possess a biological “memory” of obesity, which could explain why many individuals struggle to maintain weight loss. The study identifies a molecular circuit involving TGF-β1, fibrillin-1, and asprosin—a hormone produced by fat tissue that stimulates appetite. In mouse models, this mechanism remained active even after weight loss, promoting weight regain.

This phenomenon occurs because obesity may cause persistent modifications in adipose cell activity through gene regulation changes. Specifically, an increase in TGF-β1 signaling activates the Fbn1 gene, which encodes fibrillin-1, ultimately influencing asprosin levels.

Beyond biological mechanisms, common behavioral errors can also hinder weight management. These include failing to follow personalized nutritional plans, incorrect food combinations, unmeasured caloric intake from oils, frequent snacking, and high stress levels, which can increase fat mass and reduce muscle mass.