Seattle Seahawks favorited for Week 2 matchup against Arizona Cardinals

NFL Seattle Seahawks Arizona Cardinals sports betting Week 2

The Seattle Seahawks are scheduled to face the Arizona Cardinals in an NFL Week 2 matchup on Sunday, September 20, 2026, at State Farm Stadium. Kickoff is set for 4:25 PM ET.

Betting markets and predictions favor the Seahawks as heavy favorites. Polymarket currently prices Seattle at a 72% probability of winning, while Arizona holds a 30% chance. The moneyline for Seattle is set at -218, compared to +188 for the Cardinals. While the Seahawks are expected to win, the spread suggests a competitive margin, with a 52% chance of Seattle winning by more than 6.5 points.

Seattle's offense is expected to be a focal point, with bettors pricing a 76% chance of the team scoring over 26.5 points. The Seahawks' backfield remains shorthanded as leading rusher Zach Charbonnet remains on the reserve/PUP list following an ACL injury. Rookie Jadarian Price, George Holani, and Emanuel Wilson are expected to handle the rushing duties.

Entities

Arizona Cardinals · Polymarket · Seattle Seahawks · State Farm Stadium · Zach Charbonnet

Sources

Commanders vs. Cowboys Betting Odds, Free Picks, and Predictions - 4:25 PM ET (Sun, Sep 20, 2026) [www.cappertek.com]

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Experts release Seahawks vs. Cardinals prediction as Seattle enters week 2 as heavy favorite [www.oregonlive.com]

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NFL Power Rankings Week 2 Roundup: Seahawks Soaring Despite Injury Concerns [www.si.com]

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How to watch Commanders vs. Cowboys: TV channel and streaming options for September 20 [www.nytimes.com]

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