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[HEALTH] · South Korea · 3 sources

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Seoul National University Hospital identifies new indicator for cardiomyopathy sudden death risk

hypertrophic cardiomyopathy sudden death prediction Left Atrial Reservoir Strain echocardiography medical research

A research team from Seoul National University Hospital has identified a new indicator to more accurately predict sudden death in patients with hypertrophic cardiomyopathy. By analyzing 1,761 patients from Seoul National University Hospital and Samsung Medical Center over a median of 6.8 years, researchers found that Left Atrial Reservoir Strain (LARS) is a critical predictor.

Specifically, patients with a LARS value below 21% face a six-fold higher risk of sudden death events compared to those with a value of 21% or higher, even among those previously categorized as low-to-intermediate risk by the standard European Society of Cardiology risk score (HCM Risk-SCD).

Integrating the LARS metric into existing evaluation models improved the accuracy of identifying high-risk patients, increasing the Area Under the Curve (AUC) from 0.63 to 0.73. Because LARS can be measured using standard echocardiography with specialized software, it offers a practical way to refine preventative treatments, such as the use of implantable cardioverter-defibrillators (ICD), in clinical settings. The findings were published in the Journal of the American Society of Echocardiography.

Entities

Journal of the American Society of Echocardiography · Kim Hyung-kwan · Kwak Soon-gu · Samsung Medical Center · Seoul National University Hospital

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Sources

서울대병원, '좌심방 저장 변형률 '수치 활용한 심근증 돌연사 예측 - 메디칼허브 [www.healthmedia.co.kr]
'저·중간 위험' 비후성 심근증도 LARS 21% 미만이면 돌연사 위험 약 6배 - Health Issue&News [www.hin.company]
비후성 심근증 돌연사 위험, 좌심방 변형률로 더 정밀하게 가려낸다 [www.seoul.co.kr]