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[HEALTH] · Spain · 3 sources

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Part of situation: Global and regional hormone replacement therapy shortages (12 clusters)

Spain's Aemps warns against magistral estrogen use amid hormone therapy shortages

hormone replacement therapy medicine shortage magistral formulas estradiol Aemps

The Spanish Agency of Medicines and Medical Products (Aemps) has issued a warning regarding the use of magistral estrogen formulas as a response to widespread shortages of hormone replacement therapies. Aemps stated that these pharmacy-prepared formulas should be a last resort because they exhibit significantly lower and more variable hormone absorption levels compared to authorized industrial medications such as gels, patches, or sprays.

The shortage of the estradiol spray Lenzetto has triggered a ripple effect, increasing demand for other treatments like patches and creams, which has also led to supply issues for products such as Evopad 25, Bijuva, and Estradot 75.

In response to the crisis, the Catalan Health Department has indicated it may authorize local pharmacies to prepare magistral estradiol formulas if the supply shortage is not resolved within one month. While this provides an alternative for menopausal women and transgender individuals, Aemps maintains that the lack of data on absorption rates and the influence of various excipients make these preparations less reliable than standardized industrial drugs.

Entities

Agencia Española de Medicamentos y Productos Sanitarios · Catalonia · Departament de Salut · Lenzetto

Claims

What the coverage asserts, and how many sources carry each claim.

  • [○ 1 SOURCE] The shortage of Lenzetto has been ongoing since March 16. www.lavanguardia.com
  • [● 2 SOURCES] The shortage of the spray Lenzetto has caused increased demand for other hormone therapies, including patches and creams. www.europasur.es · www.lavanguardia.com
  • [○ 1 SOURCE] Magistral preparations show significantly lower and more variable hormone absorption levels compared to authorized industrial products like gels or patches. www.europasur.es
  • [○ 1 SOURCE] The Catalan Health Department may authorize pharmacies to prepare magistral estradiol formulas if supply shortages are not resolved within one month. www.lavanguardia.com
  • [○ 1 SOURCE] The Spanish Agency of Medicines and Medical Products (Aemps) advises that magistral formulas of estrogens should only be used as a last resort due to shortages of hormone replacement therapies. www.europasur.es

Sources

Catalunya autorizará a las farmacias a elaborar terapias hormonales si en un mes sigue el desabastecimiento [www.lavanguardia.com]
La escasez de tratamientos hormonales sustitutivos enfrenta a autoridades sanitarias y farmacéuticos [www.europasur.es]
La escasez de tratamientos hormonales sustitutivos enfrenta a autoridades sanitarias y farmacéuticos [www.diariodealmeria.es]