Spermidine anti-aging potential faces scientific scrutiny

Spermidine, a polyamine found in wheat germ, aged cheese, and mushrooms, is widely promoted in the longevity community for its ability to trigger autophagy and potentially slow the aging process. While laboratory studies on yeast, worms, flies, and mice have shown increased lifespans, clinical results in humans have been underwhelming.

Recent scientific concerns have emerged regarding the substance's safety. A study from Japan indicates that spermidine may also promote the growth of cancer cells, leading researchers to view the anti-aging supplement with increased caution.