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Florida vaccine mandate changes could trigger historic measles epidemic

A new mathematical model published in the Proceedings of the National Academy of Sciences (PNAS) warns that the United States could face its largest measles epidemic in 500 years. The study, conducted by researchers at the University of Maryland, highlights a significant resurgence of the disease, noting a 650% increase in cases between 2024 and 2025, totaling 3,471 confirmed cases across 45 states, New York City, and Washington D.C.

The research specifically examines the potential impact of Florida removing its school-entry vaccine mandates for the measles, mumps, and rubella (MMR) shot. In a worst-case scenario where kindergarten vaccination rates in the state fall to 82%, the model projects a major epidemic within three to five years, with infection rates potentially exceeding any level seen in the U.S. since 1977. Researchers also suggest that such outbreaks could become a recurring fixture in Florida for up to 50 years.

Experts emphasize that measles is one of the most contagious human pathogens. The study found that vaccinating children is approximately three times more effective at reducing transmission than vaccinating adults. Current trends in vaccine hesitancy and the potential for policy changes regarding mandates are cited as primary drivers for the risk of losing the country's measles-free status.

Entities

Abba Gumel · Alice Oveson · Florida · Proceedings of the National Academy of Sciences · United States · University of Maryland

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