University of Guelph identifies new pathway to combat leukemia

Researchers at the University of Guelph have identified a potential vulnerability in acute myeloid leukemia, an aggressive form of blood cancer. The study reveals that cancer cells rely heavily on a specific type of fat for survival, whereas healthy cells can utilize alternative energy sources.

Investigators discovered a protein present at high levels in leukemia cells that is essential for processing these fats. Using this finding, they developed a plant-based compound, derived from a plant used in the cosmetics industry, capable of blocking this mechanism. When the process is interrupted, the cancer cells lose their primary energy source and are destroyed, while healthy cells remain unaffected.

Initial laboratory results show a reduction in leukemia cells and improved survival rates without significant adverse effects. While the research is in its early stages and not yet a clinical treatment, the next steps involve refining the compound and conducting human trials to develop more targeted therapies.