University of Murcia researchers test stem cell therapy for osteoporosis

A research team led by the University of Murcia has reported promising results from a small clinical trial involving a ‘living medication’ to treat advanced osteoporosis. The study focused on 10 women, aged 51 to 72, who suffered from severe osteoporosis and frequent fractures.

The treatment involves extracting mesenchymal stromal cells (MSCs) from the patients' own bone marrow. To overcome the challenge of getting these cells to reach the bone tissue, researchers used fucose to modify the cells' surface glycocalyx. This modification helps the cells better navigate to and enter the bone tissue.

Following a single infusion, a six-year follow-up showed that the frequency of low-impact fractures decreased significantly. Before the treatment, patients averaged one fracture every one to two years; after the treatment, the frequency dropped to approximately once every ten years. Imaging also indicated improvements in bone density and size.

While these results are encouraging for regenerative medicine, researchers noted that the study is limited by its small sample size and lack of a control group. Further clinical trials are required to confirm the efficacy and long-term safety of this method.