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[HEALTH] · Australia · 24 sources

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Part of situation: University of Sydney circadian depression research (2 clusters)

University of Sydney researchers identify circadian depression subtype

circadian depression University of Sydney biological clock mental health research sleep-wake cycle

Researchers at the University of Sydney have identified a new subtype of depression, termed “circadian depression,” which is linked to disruptions in the body’s internal 24-hour biological clock. The study, published in the British Journal of Psychiatry, analyzed clinical and genetic data from over 10,000 Australians participating in the Australian Genetics of Depression Study.

Approximately one-quarter of the participants—2,604 individuals—met the criteria for this subtype. Key characteristics include seasonal symptom patterns, sleeping longer during depressive episodes, waking up feeling exhausted, and a tendency to be a “night owl.” The research also noted a phenomenon described as “social jet lag,” where biological rhythms mismatch social routines.

Findings suggest that individuals with circadian depression may experience more severe symptoms, including higher rates of mania, suicidal ideation, and earlier onset of the illness. Genetically, this group showed a higher predisposition to ADHD, inflammatory conditions, and cardiovascular issues.

Crucially, the study indicates that this subtype may be more resistant to traditional treatments like selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT). Instead, researchers suggest that therapies targeting circadian rhythms, such as light therapy and melatonin-based treatments, may offer more effective alternatives.

Entities

Brain and Mind Centre · British Journal of Psychiatry · Emiliana Tonini · Ian Hickie · The British Journal of Psychiatry · University of Sydney

Claims

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Sources

علوم وصحة - دراسة أسترالية تكشف نوعاً فرعياً من الاكتئاب مرتبطاً بالساعة البيولوجية [www.abyan-time.net]
شناسایی زیرگونه‌ای از افسردگی مرتبط با ساعت زیستی بدن [www.khabarfoori.com]
دانشمندان نوع جدیدی از افسردگی را شناسایی کردند [negarmag.com]
تنام طويلًا وتستيقظ مرهقًا؟ دراسة تربط هذه العلامات بنمط من الاكتئاب [wahhnews.com]
Estudo liga depressão a alterações no relógio biológico [brasilemfolhas.com.br]
Un nou subtip de depresie, legat de ceasul biologic, identificat de cercetători - Feminis.ro, inspiratie zi de zi [www.feminis.ro]
Circadian depression: New research suggests SSRIs and CBT therapy not suitable for all forms of depression [www.watoday.com.au]
Study identifies a body-clock pattern in depression [knowridge.com]
Researchers Identify New Depression Subtype Linked To Body Clock [www.newsmobile.in]
Depression subtype discovery gives hope to sufferers [startsat60.com]
What is ‘circadian depression’? Australian scientists discover new type of depression [www.womensweekly.com.au]
Depression subtype discovery gives hope to sufferers [www.perthnow.com.au]
Circadian depression: New research suggests SSRIs and CBT therapy not suitable for all forms of depression [www.smh.com.au]
Scientists Discover a Depression Subtype Linked to the Body's Internal Clock [medicaldialogues.in]
What Is Circadian Depression? Study Finds A Subtype Linked To Sleep Patterns, Seasonal Changes [news.abplive.com]
Estudo propõe novo subtipo de depressão ligada ao relógio biológico [revistagalileu.globo.com]
دراسة تكشف نمطاً من الاكتئاب يرتبط بالساعة البيولوجية... ما أعراضه؟ [sana.sy]
expert reaction to observational study on ‘circadian subtype’ of depression [www.sciencemediacentre.org]
Researchers Identify Subtype of Depression Linked to Body's Internal Clock [www.deccanchronicle.com]
Scoperto un nuovo sottotipo di depressione legato ai ritmi circadiani [www.focus.it]
Pesquisa identifica novo subtipo de depressão ligado ao relógio biológico [www.metropoles.com]
Researchers identify new depression subtype linked to the body clock [www.news-medical.net]
Circadian depression: New research suggests SSRIs and CBT therapy not suitable for all forms of depression [www.theage.com.au]
Body clock disruptions contribute to one in four cases of depression, suggests large study [www.nature.com]