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University of Texas researchers find adult castration increases mouse longevity
Researchers at the University of Texas Health Science Center at San Antonio have discovered that adult castration in male mice significantly increases lifespan. In a study published on bioRxiv, scientists observed that mice castrated at 240 days of age lived an average of 32.9% longer than control groups.
The study utilized genetically diverse UM-HET3 mice, a population where females typically outlive males. To determine the timing of the impact of sex hormones on longevity, researchers performed the procedure at three different stages: 20 days (pre-puberty), 60 days (post-puberty), and 240 days (adulthood).
Unexpectedly, the greatest increase in survival occurred when the intervention was delayed until adulthood. Castration at 20 days resulted in a 19.3% increase in survival, while castration at 60 days yielded a 25.8% increase. The findings suggest that the influence of the testes on aging may change as the animal matures, though the study has not yet undergone peer review.
Entities
James Nelson · Laurence Maeyens · University of Texas Health Science Center at San Antonio · bioRxiv
Claims
What the coverage asserts, and how many sources carry each claim.
- [● 2 SOURCES] Castration at 60 days increased survival by 25.8%. www.farodevigo.es · www.diariodeibiza.es
- [● 3 SOURCES] The research was published on bioRxiv and has not yet been peer reviewed. www.farodevigo.es · es.gizmodo.com · www.diariodeibiza.es
- [● 3 SOURCES] Mice castrated at 240 days of age lived 32.9% longer than control groups. www.farodevigo.es · es.gizmodo.com · www.diariodeibiza.es
- [○ 1 SOURCE] The study used genetically diverse UM-HET3 mice. es.gizmodo.com
- [● 2 SOURCES] Castration at 20 days increased survival by 19.3%. www.farodevigo.es · www.diariodeibiza.es