University of Texas study links physical activity to reduced depression symptoms

A large-scale observational study led by the University of Texas at San Antonio has identified a connection between physical activity and the severity of depressive symptoms. Published in Nature Mental Health, the research utilized data from 23,517 participants in the National Institutes of Health’s ‘All of Us’ program.

By combining whole-genome sequencing, electronic health records, and long-term Fitbit activity data, researchers examined how habitual movement interacts with polygenic risk scores for major depressive disorder (MDD). The findings suggest that while physical activity may not prevent the onset of MDD in those with a genetic predisposition, it appears to influence the severity of symptoms.

Specifically, the study noted that individuals with a higher genetic risk for depression showed different patterns of symptom severity in relation to their daily step counts and moderate-to-vigorous physical activity. However, the researchers emphasized that the study provides an association rather than a definitive causal proof.