University of Udine launches chromosome modification research

The University of Udine has launched a five-year research project aimed at modifying entire chromosomes in diseased cells to advance genetic therapies. Coordinated by Gianluca Petris at the Department of Medicine, the initiative has received approximately 1.3 million euros in funding from the Italian Ministry of University and Research through the Italian Fund for Science, with additional support from the Italian Foundation for Liver.

While current genome editing techniques focus on precise modifications of single genes or small DNA segments, this project seeks to develop technologies for the transfer, modification, and replacement of entire chromosomes. This approach aims to address complex or rare genetic diseases involving large genomic regions or multiple genes that are difficult to treat with existing methods. The long-term goal is to validate the safety and feasibility of “universal cellular therapies” by using healthy, engineered chromosomes to generate therapeutic cells.

Beyond treating genetic disorders, the research may provide new tools for studying large-scale genomic alterations, including those related to tumor development and aging processes. The project also intends to deepen scientific understanding of how cells organize and control vast amounts of genetic information.