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[TECHNOLOGY] · United Kingdom · 3 sources

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University of York and Sheffield researchers observe DNA helix connection

Researchers from the Universities of York and Sheffield have successfully visualized how DNA double helices connect, resolving a long-standing biological paradox. Because the exterior of DNA carries negative electrical charges, the helices should theoretically repel each other like similar poles of magnets.

Using high-resolution atomic force microscopy, the team observed that the helices overcome this repulsion by precisely aligning their spiral grooves. The connection is stabilized by positively charged ions that act as tiny bridges between the molecules. These findings, published in the journal Nucleic Acids Research, provide direct evidence for a model that scientists have discussed for over 20 years.

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Nucleic Acids Research · University of Sheffield · University of York

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