Uterus transplantation shows improved outcomes and successful births in U.S. study

A national review led by researchers at the University of Pennsylvania’s Perelman School of Medicine indicates that uterus transplantation has transitioned from an experimental procedure to a replicable clinical therapy. The study, published in Obstetrics & Gynecology, analyzed outcomes from 60 transplants performed at four U.S. centers between 2016 and 2025.

Findings show that 70 percent of recipients achieved at least one live birth or were pregnant beyond 20 weeks at the time the study concluded. The research covers surgical, reproductive, neonatal, and early childhood developmental outcomes, representing nearly the entire U.S. experience with the procedure to date.

The procedure targets absolute uterine factor infertility, which affects approximately 3 percent of women. Many recipients in the study presented with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a congenital condition where the uterus fails to develop.