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2 clusters · 5 sources · 3 days · First seen · Last updated

Advancements in gene therapy control technologies

Overview

Researchers have reported advancements in gene therapy technology focused on improving the precision and delivery of gene expression control.

At Dongguk University in South Korea, a team led by Professor Jongpil Kim developed an electromagnetic field (EMF)-responsive gene switch. Utilizing the promoter of the Lgr4 gene, this tool allows for non-invasive, reversible, and precise control over gene expression. Testing in mouse models has shown potential for reversing aging markers and modeling Alzheimer’s disease.

Concurrently, scientists at Stanford Medicine developed an ultracompact gene activation tool named TIGRa. Designed to overcome the size limitations of bulky CRISPR-based systems, TIGRa is small enough to be packaged into a single adeno-associated virus. In mouse models of retinal degeneration, the tool was used to activate protective genes in retinal ganglion cells, helping subjects retain partial vision compared to untreated subjects. This development suggests potential applications for treating glaucoma and other retinal degenerative conditions.

Entities

Stanford Medicine · Yang Sun · Cell Stem Cell · Dongguk University · TIGRa

Timeline

  1. 12 days ago

    [HEALTH] 3 sources
    Stanford Medicine researchers develop ultracompact TIGRa gene activation tool

    Stanford Medicine researchers developed TIGRa, an ultracompact gene activation tool that fits into viral vectors to more efficiently trigger protective genes for treating diseases like glaucoma.

  2. 15 days ago

    [TECHNOLOGY] 2 sources
    Researchers develop new tools for precise gene therapy control

    Scientists have developed new gene therapy tools: an EMF-responsive switch for non-invasive control and TIGRa, an ultracompact tool for efficient gene activation in viral vectors.

Sources

azolifesciences.com · ddw-online.com · levante-emv.com · news-medical.net · ocio.diariodemallorca.es