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Cellular rejuvenation research in Germany

Overview

Researchers at the University of Bonn and the University Hospital of Bonn have developed a method to rejuvenate human cells by reprogramming red blood cell precursors directly into neural stem cells. This direct reprogramming process bypasses the intermediate pluripotent stem cell stage, allowing for a controlled observation of cellular transformation over approximately 50 to 100 days.

In a study published in the journal ‘Aging Cell’, scientists successfully transformed cells from an 80-year-old donor into stem cells with a molecular age of less than 20 years. By using transcription factors like SOX2 and c-MYC, the team was able to reset epigenetic molecular clocks.

Professor Dr. Oliver Brüstle noted that unlike previous rapid two-step processes, this technique enables detailed observation of how cell identity and age markers change. The breakthrough provides a model for studying biological aging and neurodegeneration.

Entities

Oliver Brüstle · University of Bonn · Aging Cell · University Medical Center Maastricht · University Hospital of Bonn

Timeline

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    University of Bonn researchers rejuvenate human cells

    University of Bonn researchers have successfully rejuvenated human cells in a test tube, resetting the molecular age of cells from an 80-year-old donor to under 20 years during neural reprogramming.

Sources

24matins.es · azolifesciences.com · dziennik.pl · fehmarn24.de · hna.de · kreiszeitung.de · kurierverlag.de · leinetal24.de · mannheim24.de · merkur-online.de · merkur.de · nlc.org.uk · op-online.de · rmf24.pl · tz.de · viva.co.nz · world-today-news.com