Denver Broncos and San Francisco 49ers Week 4 matchup

The Denver Broncos and San Francisco 49ers are preparing for their Week 4 matchup at Levi’s Stadium. The 49ers hold a 3-0 record, while the Broncos are 2-1 following two consecutive home victories.

Ahead of the game, the 49ers received defensive boosts as Dre Greenlaw (quadricep) and Keion White (hamstring) returned to practice. Tackle Trent Williams was also available following a neck injury sustained in Week 3. Wide receiver Mike Evans was present in uniform but was observed running on the side rather than participating in full team drills due to a rib injury.

In preparation for the matchup, the Broncos have adjusted their roster by signing fullback Adam Prentice to the 53-man roster. To facilitate this move, the team released wide receiver Lil’Jordan Humphrey, though reports suggest he could potentially return as a member of the practice squad.

Denver’s defense, coordinated by Vance Joseph, has recently led the league in sacks. The matchup features several former 49ers now playing for the Broncos, including DJ Jones, Mike McGlinchey, and Talanoa Hufanga. Key tactical storylines involve the matchup between coaches Kyle Shanahan and Sean Payton, with Payton noting quarterback Brock Purdy’s decisiveness and the 49ers’ efficiency in the red zone.