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Genetic and immune links to extreme longevity

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2026-08-28 07:06 UTC → 2026-08-28 07:20 UTC · added ~~removed~~

Research involving thousands of participants in the United States and the United Kingdom suggests that extreme longevity and healthy aging are linked to genetic inheritance and specific immune system characteristics. Studies published in JAMA Network Open, involving data from over 4,000 individuals across three long-term studies, indicate that the health benefits of living to 100 may be hereditary. Researchers from the Albert Einstein College of Medicine compared the offspring of centenarians to those whose parents died by age 85. The findings show that children of centenarians possess significant biological advantages, including a 33% lower risk of cardiovascular disease, a 32% lower risk of hypertension, and a 42% lower risk of death from natural causes. These advantages persist regardless of lifestyle factors such as diet, exercise, smoking, or socioeconomic status. Specifically, the onset of hypertension was found to be delayed by approximately five years, and mortality occurred about three years in later on average compared to the control group. While these ~~individuals.~~ hereditary advantages are notable, the research found no significant difference in the risk of cancer or stroke. Further findings suggest that longevity may be associated with a higher abundance of CD4 cytotoxic T cells, which may assist the body in maintaining its ability to adapt to threats at advanced ages. Scientists hope these findings will help identify specific hereditary traits to develop treatments that mimic natural longevity mechanisms.

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