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2 clusters · 7 sources · 5 days · First seen · Last updated
Genetic research into anorexia nervosa risk
Overview
Researchers at Michigan State University have identified a potential genetic link between the PLIN4 gene and anorexia nervosa. A study published in ‘Frontiers in Psychiatry’ suggests the disorder may have metabolic components, as the PLIN4 gene regulates how cells store lipids in muscle and fat tissue.
In a study of 154 patients, rare and potentially damaging variants of the PLIN4 gene were found in approximately 11% of participants, compared to a 3% prevalence in a large genetic reference database. Because PLIN4 is primarily active in body fat and muscle rather than the brain, researchers noted the finding could open new avenues for investigating how fat metabolism and energy use contribute to the development of the disorder.
Entities
Michael Lutter · Michigan State University · Jonas Holst Wolff · University of Iowa · PLIN4
Timeline
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[HEALTH] 3 sourcesGenetic research reveals new links to anorexia and breakthroughs in gene editing
New research links the PLIN4 gene to anorexia via fat metabolism, while Aarhus University scientists use prime editing to successfully repair genetic defects in immune-related stem cells.
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[HEALTH] 4 sourcesPLIN4 gene variants linked to anorexia nervosa risk
A study published in ‘Frontiers in Psychiatry’ links rare variants of the PLIN4 gene, which regulates fat storage, to an increased risk of anorexia nervosa, suggesting a metabolic component to the disorder.
Sources
illvet.se · illvid.dk · larazon.es · medicaldaily.com · news-medical.net · noticias24hrs.com.ve · via.ritzau.dk