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2 clusters · 5 sources · 18 days · First seen · Last updated
Genetic research into autoimmune disease mechanisms
Overview
Recent scientific research has provided new insights into the genetic foundations of autoimmune diseases.
An initial study by the Garvan Institute of Medical Research and UNSW Sydney identified over 1,000 genetic switches that cause immune cells to function differently between men and women. These switches, described as molecular ‘volume controls’, reside largely on autosomes and may explain why women often have stronger immune responses but face higher risks of diseases like lupus.
Subsequent research from the Karolinska Institutet, utilizing Swedish national registers of millions of individuals, found that autoimmune diseases form distinct genetic clusters based on the specific tissues or organs they affect. The study suggests that rather than a universal predisposition, genetic connections are organized by physiological systems, such as connective tissue, endocrine, or gastrointestinal clusters.
Entities
The American Journal of Human Genetics · Garvan Institute of Medical Research · Karolinska Institutet · The Journal of Clinical Investigation · UNSW Sydney
Timeline
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4 days ago
[HEALTH] 2 sourcesKarolinska Institutet study reveals genetic clusters in autoimmune diseasesA study of 6.3 million individuals in Sweden reveals that autoimmune diseases form genetic clusters based on the organs or tissues they affect, rather than sharing a single common genetic basis.
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22 days ago
[HEALTH] 3 sourcesGarvan Institute study identifies 1,000 genetic switches driving sex differences in immunityA study by the Garvan Institute and UNSW Sydney identified 1,000+ genetic switches that cause sex-based differences in immune cell function, explaining higher autoimmune disease rates in women.
Sources
aftabnews.ir · arynews.tv · imfarmacias.es · negarmag.com · newswise.com