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2 clusters · 6 sources · 4 days · First seen · Last updated

Genetic research on OCD and tic disorders

Overview

Researchers have identified 36 high-confidence genes associated with obsessive-compulsive disorder (OCD) and chronic tic disorders (CTD), such as Tourette disorder. Using whole exome sequencing on data from nearly 4,000 individuals, including over 2,400 parent-child trios, the study published in Nature Neuroscience reveals a significant genetic overlap, with 83% of the identified genes linked to both conditions.

The findings suggest biological connections between OCD, CTDs, autism, and schizophrenia, specifically highlighting brain circuits involved in impulse control, movement, and habit formation. Experts indicate that these discoveries provide the pharmaceutical industry with new opportunities to develop treatments that target underlying genetic and signaling networks rather than focusing solely on symptom management.

Entities

Gary Heiman · Nature Neuroscience · Rutgers University · Rutgers School of Arts and Sciences · Jay Tischfield

Timeline

  1. 5 days ago

    [HEALTH] 3 sources
    Rutgers University researchers identify 36 genes linked to OCD and tic disorders

    A Rutgers University study has identified 36 genes linked to OCD and chronic tic disorders, revealing shared biological connections with autism and schizophrenia.

  2. 9 days ago

    [HEALTH] 3 sources
    Researchers identify 36 risk genes for OCD and chronic tic disorders

    Researchers have identified 36 high-confidence genes linked to obsessive compulsive disorder and chronic tic disorders, offering new potential targets for pharmaceutical treatment development.

Sources

azolifesciences.com · generation-nt.com · insideprecisionmedicine.com · it-boltwise.de · journaldemontagnes.com · sciencealert.com