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Genetics, obesity and tumor evolution linked to cancer risk
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2026-07-27 05:25 UTC → 2026-07-27 18:46 UTC ·
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Genetics and Genetics, obesity impact and tumor evolution linked to cancer risk
A July 23 study by the German Cancer Research Center (DKFZ) analyzed data from the Germany’s DKFZ, using UK Biobank covering data from 458,000 participants. It found adults, showed that excess body weight—particularly weight—especially abdominal fat measured by waist circumference and waist‑to‑hip ratio—could account for more than over ten percent of all cancer cases, indicating that obesity cancers, highlighting metrics beyond BMI provide a as stronger link to cancer incidence. predictors. In parallel, DKFZ‑led mouse experiments showed demonstrated that an individual’s genetic makeup strongly shapes tumor development, development even under identical carcinogen exposure, with different diverse genetic routes converging on the MAPK signaling pathway. Three A few days later, a collaborative mouse study involving Cambridge, Edinburgh and other European and U.S. institutions institutes reported direct evidence that inherited genetic background alters susceptibility to liver cancer induced by the carcinogen diethylnitrosamine. Published in *Nature*, the work highlighted that genetic variation influences tumor formation and progression, diethylnitrosamine, underscoring the need for personalized cancer‑prevention and screening strategies that account for consider both genetics and environmental risk factors. The latest evidence, published in Nature (2026), expands this picture: four genetically distinct mouse strains exposed to the same dose of diethylnitrosamine produced nearly 600 tumors that followed different evolutionary trajectories, yet many ultimately activated the same biological pathways. The authors argue that cancer‑risk assessment and therapy must incorporate inherited genetics and population diversity to achieve truly personalized strategies.
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- 2026-07-27 18:46 UTC Genetics, obesity and tumor evolution linked to cancer risk
- 2026-07-27 05:25 UTC Genetics and obesity impact cancer risk
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