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Gut microbiome research and cancer treatment

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2026-10-06 10:41 UTC → 2026-10-11 16:20 UTC · added removed

Research has increasingly highlighted the connection between diet, the gut microbiome, and various health outcomes, including the efficacy of cancer treatments. Initial findings suggest that a healthy microbiome, supported by high fiber intake and fermented foods, can manage weight and reduce risks for cardiovascular and brain diseases. In oncology, studies have explored the “obesity paradox,” suggesting that specific diets and gut bacteria may interact with the immune system to enhance immunotherapy responses. Building on this, a Mayo Clinic study published in the journal Cell has identified specific gut microbiome signatures that may serve as biomarkers for various cancers. By analyzing stool samples from over 1,300 patients, 1,364 patients and comparing them with 287 healthy individuals, researchers found distinct microbial patterns identified 341 bacterial species associated with five major cancer groups. These microbial patterns were particularly notable in younger patients, such as those with early-onset colorectal and breast cancers. These microbial signatures In patients aged 50 and younger with colorectal cancer, researchers observed higher lactate levels and an increase in the bacterium Veillonella parvula. Early-onset breast cancer was associated with changes across 64 bacterial species and lower levels of primary bile acids. Other findings included a widespread loss of health-associated bacteria in neuroendocrine tumors, elevated levels of Enterococcus faecalis in liver and intrahepatic bile duct cancers, and increased levels of Streptococcus in esophageal cancer. While these associations offer potential for predicting cancer progression and chemotherapy side effects. effects, researchers noted that the study does not prove these bacteria cause cancer.

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  1. 2026-10-11 16:20 UTC Gut microbiome research and cancer treatment
  2. 2026-10-06 10:41 UTC Gut microbiome research and cancer treatment

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