Monitor this situation.
Unsubscribe anytime.
[SITUATION] · [QUIET] · [HEALTH]
3 clusters · 8 sources · 31 days · First seen · Last updated
Pancreatic cancer resistance mechanisms
Overview
Scientific research has identified two distinct mechanisms that contribute to the resilience and treatment resistance of pancreatic cancer.
Initial findings revealed that certain cells, described as “architects,” manipulate the protein fibrin to create a structural network. This network acts as a “biological shield” that protects the tumor mass from the immune system by preventing natural protein degradation.
Subsequent studies involving single-cell analysis of pancreatic ductal adenocarcinoma (PDAC) have further detailed how tumor subpopulations evade medical intervention. Researchers discovered that cancer cells continuously reshape their DNA, allowing different clones to evolve in parallel within a single tumor. This genetic heterogeneity enables specific cell clusters to resist therapy and drives metastasis.
Recent research, including studies by NYU Langone Health and UC San Diego, has expanded on this genetic reconfiguration. By analyzing nearly half a million single cells, investigators found that these subpopulations can transition between different subtypes, such as shifting from classical to more aggressive basal subtypes. This evolutionary process is often marked by increased activity in specific genes, such as MYC, which facilitates the cancer's ability to spread and resist medical treatments.
Entities
Nature Genetics · NYU Langone Health · UC San Diego · Perlmutter Cancer Center · Moores Cancer Center
Timeline
-
[HEALTH] 2 sourcesPancreatic cancer cells rewire DNA to resist treatment and spread
A study led by NYU Langone Health reveals that pancreatic cancer cells rewire their DNA to evade treatment and transition into more aggressive subtypes, driving metastasis.
-
[HEALTH] 4 sourcesPancreatic cancer cells reshape DNA to evade treatment
A study by UC San Diego and NYU researchers reveals that pancreatic cancer cells continuously reshape their DNA, creating diverse clones that enable treatment resistance and rapid metastasis.
-
[HEALTH] 2 sourcesPancreatic cancer cells use fibrin to create a biological shield
Researchers discovered that certain “architect” cells in pancreatic tumors manipulate fibrin to create a protective biological shield that repels the immune system.
Sources
accc.org.uk · centre-cerlatez.ch · digitalcommons.library.tmc.edu · farmacoecura.it · finde.latercera.com · ma-clinique.fr · microbiologiaitalia.it · news-medical.net
This summary has been updated 1 time: see revision history