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2 clusters · 7 sources · 17 days · First seen · Last updated

UCSF cancer research and immunotherapy advancements

Overview

Researchers at the University of California, San Francisco (UCSF) are advancing precision medicine and immunotherapy through new modeling and cellular platforms.

Initial developments focused on using lab-grown mini tumors, or organoids, to predict how different breast cancers respond to various therapies. By placing patient-derived tumor cells into specialized gels, scientists created models that successfully reflected the biological characteristics of actual tumors, aiding in the identification of effective treatments for aggressive cancers.

Subsequent research expanded into enhancing immunotherapy for solid tumors. This includes the use of a genome-wide CRISPR screening platform to identify genetic edits that improve the ability of CAR-T cells to infiltrate and eliminate tumors. Additionally, researchers developed a dendritic-cell platform using induced pluripotent stem cells to create a renewable source of immune cells capable of presenting a patient’s unique tumor targets to T cells.

Entities

I-SPY2 trial · University of California, San Francisco · Jennifer M. Rosenbluth · UCSF · Gladstone Institutes

Timeline

  1. 26 days ago

    [HEALTH] 7 sources
    UCSF researchers develop new platforms to enhance cancer immunotherapy

    Scientists at UCSF and Gladstone Institutes have developed new CRISPR screening and dendritic-cell platforms to improve immunotherapy effectiveness against solid tumors.

  2. about 1 month ago

    [HEALTH] 2 sources
    UC San Francisco researchers use lab-grown mini tumors to predict breast cancer treatment success

    UC San Francisco researchers have developed a method using lab-grown breast cancer organoids to predict treatment responses, potentially enabling more personalized and effective precision medicine.

Sources

bioquicknews.com · cancerresearch.org · european-biotechnology.com · gulfnews.com · hispanospress.com · insideprecisionmedicine.com · news-medical.net