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US clinical guidelines for menopause management

Updated 1 time since CLSTR started tracking revisions of this situation.

What changed

2026-10-20 18:47 UTC → 2026-10-24 11:01 UTC · added removed

Medical organizations in the United States have issued updated clinical guidelines regarding the management of menopause symptoms, such as vasomotor symptoms, insomnia, and mood changes. The American College of Physicians (ACP) recommended hormone therapy as a first-line treatment for perimenopausal and postmenopausal females experiencing vasomotor symptoms. The ACP suggested second-line treatments like SNRIs and third-line options including SSRIs, gabapentin, or NK receptor antagonists for patients unable to tolerate estrogen. In response, the Physicians Committee for Responsible Medicine advocated for prioritizing dietary changes, citing research that such as the WAVS trial which suggests plant-based diets rich in soy can be as effective as hormone replacement therapy. Following this, the The American College of Obstetricians and Gynecologists (ACOG) released guidelines emphasizing individualized approaches. ACOG stated that the safety of hormone replacement therapy is “well established” for recent menopausal patients without contraindications, recommending combined estrogen and progestogen for those with a uterus. The ACOG guidelines also highlighted non-hormonal suggests starting hormone replacement therapy before age 60 or within 10 years of natural menopause to maximize benefits. Non-hormonal medical options highlighted by ACOG include neurokinin receptor antagonists like fezolinetant and elinzanetant, alongside behavioral interventions as well as certain antidepressants and gabapentin. Behavioral and lifestyle interventions, such as cognitive-behavioral therapy therapy, mindfulness, aerobic exercise, and mindfulness. acupuncture, are also noted, though clinical evidence for some varies. Regarding supplements, ACOG stated that current evidence does not support the efficacy or safety of phytoestrogens or herbal products, such as soy isoflavones and black cohosh. Additionally, research published in The American Journal of Clinical Nutrition has examined the impact of whole-food-based dietary changes and caloric restriction on the quality of life for women undergoing menopause. life.

Versions

  1. 2026-10-24 11:01 UTC US clinical guidelines for menopause management
  2. 2026-10-20 18:47 UTC US clinical guidelines for menopause management

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