Caloric restriction and diet linked to reduced chronic inflammation

New research suggests that moderate caloric restriction may influence biological mechanisms related to aging and inflammation. A study following individuals who reduced their calorie intake by approximately 14% over two years found that these participants exhibited lower levels of C3a, a protein in the complement system of the immune response.

This reduction in C3a is linked to a decrease in low-grade chronic inflammation, often referred to as inflammation of aging. Animal models further suggest that C3a levels increase with age, partly driven by immune cells in visceral fat.

Complementary dietary strategies, such as those found in the Mediterranean diet, can also help manage systemic inflammation. Consuming foods like fatty fish, extra virgin olive oil, and berries may lower inflammatory markers such as PCR and IL-6, supporting overall metabolic and intestinal health.