Columbia University study finds depression stalls new neuron growth

major depressive disorder neurogenesis hippocampus brain cell regeneration Columbia University

A study published in Nature Medicine and led by researchers at Columbia University Irving Medical Center has found that major depressive disorder (MDD) is associated with stalled neurogenesis in the hippocampus.

By analyzing approximately 500,000 brain cells from 11 patients with MDD and 19 control subjects, researchers identified that the production of new neurons is functionally compromised. Instead of a simple loss of stem cells, the data showed an accumulation of early-stage cellular states and a significant reduction in mature neurons.

The molecular analysis revealed dysregulation in genes responsible for synaptic transmission, cellular metabolism, and energy transport. Additionally, the tissue from individuals with depression exhibited heightened immune-related gene activity and markers of neuroinflammation. These findings suggest that depression may involve deeper structural and cellular changes than previously understood through neurotransmitter-centric models, potentially offering new pathways for therapeutic intervention.

Entities

Columbia University Irving Medical Center · Nature Medicine · hippocampus

Claims

What the coverage asserts, and how many sources carry each claim.

[● 5 SOURCES] The analysis included approximately 500,000 cell nuclei using genetic activity and protein distribution techniques. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com
[● 5 SOURCES] Researchers analyzed hippocampal tissue from 11 patients with major depressive disorder and 19 control subjects. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com
[● 5 SOURCES] The study was published in the journal Nature Medicine. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com
[● 5 SOURCES] Depression causes an accumulation of early-stage cellular states and a reduction in mature neurons in the hippocampus. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com
[● 5 SOURCES] Major depressive disorder is associated with stalled neurogenesis in the hippocampus. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com
[○ 1 SOURCE] Brain tissue from people with depression showed heightened immune-related gene activity and stress-related changes in gene regulation. studyfinds.com
[○ 1 SOURCE] The findings point toward genes shared with other diseases, including Alzheimer’s, lupus, and ALS. studyfinds.com
[● 5 SOURCES] The study was led by scientists from the Columbia University Irving Medical Center. www.informacion.es · www.farodevigo.es · www.lne.es · www.world-today-news.com · studyfinds.com

Sources

CEREBRO / La depresión detiene la formación de nuevas neuronas en el cerebro [www.eldia.es]

4 days ago

CEREBRO / La depresión detiene la formación de nuevas neuronas en el cerebro [www.informacion.es]

4 days ago

CEREBRO / La depresión detiene la formación de nuevas neuronas en el cerebro [www.farodevigo.es]

4 days ago

CEREBRO / La depresión detiene la formación de nuevas neuronas en el cerebro [www.lne.es]

4 days ago

How Depression Disrupts Brain Cell Regeneration: New Columbia University Study Reveals Insights [www.world-today-news.com]

6 days ago

New Brain Cell Development Appears To Stall In People With Depression [studyfinds.com]

4 days ago