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[HEALTH] · Congo - Kinshasa · 7 sources

DR Congo Ebola outbreak driven by Bundibugyo virus

The Democratic Republic of the Congo is facing its largest Ebola outbreak on record, driven by the rare Bundibugyo virus. Genetic sequencing suggests the outbreak may have begun in February, months before its official declaration on May 15. The virus is spreading rapidly, with authorities reporting over 4,200 confirmed cases and more than 1,900 deaths as of early August.

Because there are currently no approved vaccines or specific treatments for the Bundibugyo strain, the World Health Organization (WHO) has recommended prioritizing a phase 3 clinical trial for the Ervebo vaccine. While Ervebo was originally developed for the Zaire Ebola virus, preliminary animal studies indicate it may provide cross-protection and reduce mortality against the Bundibugyo variant.

Response efforts are facing significant challenges in the eastern provinces, particularly in the Ituri epicenter. These include shortages of protective gear, strikes by unpaid health workers, rebel group threats, and misinformation. Health officials noted that the virus is spreading faster than detection efforts, with 60% to 70% of new cases occurring outside of monitored contacts.

Entities

Africa Centres for Disease Control and Prevention · Bundibugyo virus · Democratic Republic of the Congo · Ervebo · Ituri province · Mohamed Yakub Janabi · Tedros Adhanom Ghebreyesus · World Health Organization

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