New Research Highlights Biological Limits to Human Lifespan

A computational study by scientists at Russia’s Skolkovo Institute and the AI Research Institute (AIRI) modeled the impact of somatic DNA mutations on ageing. Their model suggests that even if all reversible ageing mechanisms were eliminated, the steady accumulation of somatic mutations would cap human lifespan at roughly 146‑194 years, with a median estimate of about 156 years. The findings were published in the journal npj Aging in June 2026.

A separate review of more than 350 studies examined the effects of reduced protein intake on ageing. The analysis, reported in several outlets, found that lower‑protein diets—especially those limiting certain amino acids such as methionine, isoleucine and valine—extend lifespan and improve health markers in animal models (mice, rats, flies, yeast). The proposed mechanisms involve increased levels of the hormone FGF21, enhanced energy expenditure, better glucose regulation and reduced inflammation. Human evidence remains limited, and the review emphasizes that the findings pertain mainly to biology rather than dietary recommendations.

Both lines of research underscore the multifactorial nature of ageing and suggest that biological limits may be set by genetic damage and nutrient signaling pathways.