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Part of situation: Genetic study of Jonathan the tortoise (2 clusters)

Jonathan the 194-year-old tortoise reveals genetic secrets of longevity

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An international team of scientists has published a study in Science Advances detailing the genetic and epigenetic factors contributing to the extraordinary longevity of Jonathan, a 194-year-old Aldabra giant tortoise. As the world’s oldest known land animal, Jonathan provides a unique biological model for studying aging.

Researchers, led by Benjamin Vaisvil, sequenced Jonathan’s genome and analyzed his epigenome using saliva and buccal swabs. The study identified 287 unique genetic variants that distinguish him from other giant tortoises. These variants are linked to critical biological processes, including DNA repair, mitochondrial function, insulin regulation, telomere maintenance, and immune response.

Additionally, the analysis of his methylome revealed that Jonathan maintains surprisingly young patterns of gene regulation, showing a lack of the typical genetic wear-and-tear associated with advanced age. These findings offer potential insights into the mechanisms that allow certain organisms to resist age-related deterioration.

Entities

Aldabra giant tortoise · Anthropic · Claude · Dario Amodei · Jonathan · Kallel Foundation · Saint Helena · San Francisco · Science Advances · St Helena · University of Cambridge

Claims

What the coverage asserts, and how many sources carry each claim.

Sources

Descubren el secreto de la longevidad de Jonathan, la tortuga de 194 años [www.lavozdegalicia.es]
Jonathan, la tortuga de 194 años: la ciencia descubre pistas genéticas detrás de su extraordinaria longevidad | Maya Comunicación [mayacomunicacion.com.mx]
To wyjątkowe zwierzę pozwoli nam poznać tajemnicę długowieczności? Zaskakujące odkrycie naukowców [nczas.info]
Altersforschung: 194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.zeit.de]
La tortuga ‘Jonathan’ tiene 194 años y en sus genes se esconden los secretos de la longevidad [radiokollasuyo.bo]
Anti-Aging-Geheimnis von Schildkröte Jonathan (194) gelüftet [www.focus.de]
194-jährige Schildkröte: Was Jonathan übers Altern verrät | Courage Lounge | Gemeinsam besser investieren [courage-lounge.de]
Најстарија копнена животиња има скоро 200 година [sputnikportal.rs]
Najstarsze zwierzę na lądzie ma prawie 200 lat. Jak to możliwe? [zielona.interia.pl]
¿Qué secreto de longevidad atesora Jonathan, una tortuga de 194 años? [www.20minutos.es]
194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.bbv-net.de]
Reuters Science News Summary | International [www.devdiscourse.com]
World’s oldest tortoise could hold biological key to slowing human ageing [www.gbnews.com]
Mit Armbruch bis zum letzten Hindernis: Athlet aus Hessen greift wieder bei „Ninja Warrior“ an [www.hna.de]
Ο Τζόναθαν, η γιγάντια χελώνα 194 ετών, ίσως κρύβει το μυστικό της μακροζωίας [www.naftemporiki.gr]
194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.nordbayern.de]
194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.op-online.de]
194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.stimberg-zeitung.de]
Džonatan ima 194 godine: Njegovi DNK i biomarkeri čuvaju tajnu dugovečnosti [nauka.telegraf.rs]
Desde Charles Darwin hasta hoy ¿Qué secreto de longevidad atesora una tortuga de 194 años? [www.ultimahora.com]
Altersforschung: 194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.volksfreund.de]
Ερευνητές ανακάλυψαν τα γενετικά μυστικά που κρατούν τη χελώνα Τζόναθαν ζωντανή στα 194 χρόνια της [www.cnn.gr]
Altersforschung: 194-jährige Schildkröte: Was Jonathan übers Altern verrät [www.saarbruecker-zeitung.de]
World's Oldest Tortoise Could Help Foster Healthier Aging In Humans [studyfinds.com]
At 194, the World’s Oldest Tortoise Has a Surprising Secret Hidden in His DNA [www.zmescience.com]
The oldest known land animal is 194. How did he get so ancient? [www.scientificamerican.com]
Jonathan the giant tortoise, 194, offers up insight into secrets of longevity [www.theguardian.com]