Lipoprotein(a) identified as significant genetic risk factor for stroke

A recent analysis of data from three National Institutes of Health trials indicates that approximately 1 in 5 people may have elevated levels of lipoprotein(a), or Lp(a), a genetic marker for cardiovascular risk. High Lp(a) levels are associated with a 64% higher risk of stroke and a 49% higher risk of cardiovascular death.

Unlike standard cholesterol markers such as LDL or HDL, Lp(a) levels are largely determined by genetics, meaning individuals with healthy lifestyles, diets, and fitness levels can still be at high risk. The Lp(a) particle resembles LDL but contains an additional protein called apolipoprotein(a), which can contribute to plaque buildup and interfere with blood clot dissolution.

In response to these findings, the American Heart Association and the American College of Cardiology released updated guidelines in March 2026 recommending that Lp(a) be measured at least once in a person’s lifetime. Despite the risks, current data suggests fewer than 1% of people in the U.S. have been tested for this specific marker.