Melatonin use linked to heart failure risks in observational study

Recent data presented at the American Heart Association Scientific Sessions has raised questions regarding the link between long-term melatonin use and heart health. An observational study of over 130,000 adults suggested that individuals using melatonin for at least one year showed a higher incidence of heart failure compared to non-users. However, researchers emphasized that this study does not prove a cause-and-effect relationship.

The observed association may be due to “confounding by indication,” where the underlying reasons for taking melatonin—such as chronic insomnia, anxiety, or depression—are the actual drivers of increased cardiovascular risk. Furthermore, the findings were presented as a conference abstract and have not yet undergone full peer review.

Beyond cardiovascular concerns, melatonin use is associated with common side effects, particularly when taken in high doses or for extended periods. The most frequently documented reactions include daytime drowsiness, headaches, dizziness, and nausea.